Sermorelin Therapy

Sermorelin: Potential Role in Weight Management

Sermorelin, by stimulating growth hormone production, indirectly contribute to a faster metabolism. This, in theory, could help burn more calories and potentially aid weight loss. Sermorelin might contribute to increased lean muscle mass. This, in theory, could lead to a slightly boosted metabolism, potentially making it a supportive tool for weight loss efforts, especially for those struggling with obesity or weight plateaus despite diet and exercise

Sermorelin is a form of growth hormone releasing factor (GRF) that contains only the first 29 amino acids. The GRF that is produced by neurosecretory neurons in the brain contains 44 amino acids. In the 1970′s, Nobel Laureates, R. Guilleman and A. Shalley found that only the first 29 amino acids are responsible for stimulating pituitary production and secretion of hGH. Therefore, the chemical name for Sermorelin is GRH 1-29 NH 2. Sermorelin is a prescription drug, compounded by U.S. pharmacies pursuant to a physician’s prescription and patient self-injected subcutaneously.

It stimulates the pituitary gland to naturally produce increased amounts of growth hormone. Sermorelin is a truncated analog of a growth hormone releasing factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production of HGH. The increased volume of HGH produced by the pituitary gland causes an increase in the production of Insulin-Like Growth Factor-1 (IGF-1) by the liver and results in the benefits of treatment provided to the adult patient.

No, Sermorelin is a growth hormone secretagogue, which means that it stimulates the pituitary gland to produce and secrete growth hormone. Sermorelin is a small peptide containing only 29 amino acids, whereas HGH (human growth hormone) is a much larger molecule containing 191 amino acids.

As a result of sermorelin therapy, the increased volume of HGH secreted by the stimulated pituitary gland is converted by the liver into IGF-1. The increased amount of IGF-1 in the blood stream results an increase in metabolism and growth of new cells within the body’s organs and bones. This treatment is prescribed for unlabeled use in adults to increase lean muscle mass, reduce body fat, increase bone density, enhance the immune system, and strengthen the heart, as well as, other organs of the body. And since the increased volume of HGH is produced by the body’s pituitary gland, the body’s endocrine system will not allow more growth hormone to be produced by sermorelin‘s stimulation of the pituitary than the body can safely process within the endocrine self-monitoring system. Sermorelin therapy has been specifically approved for medical use in increasing growth hormone levels in children deficient in growth hormone production. Its use to increase the growth hormone and IGF-1 levels in adults is an off-label use of this prescription drug.